教授

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刘木根

时间:2009-11-10     浏览次数:


刘木根
职称职务 教授、博士生导师、华中学者
学科专业 遗传学
联系方式 联系电话: 027-87794549                    
传真: 027-87794549
电子邮箱 lium@hust.edu.cn
 
教育经历

1981-1984年,安徽省宣城师范学校, 学生

1986-1990年,南京师范大学 生物系 学士学位

1995-1998年,复旦大学遗传研究所 遗传学 硕士学位

2000-2003年,复旦大学遗传研究所 遗传学 博士学位

工作经历

1986-1986年,安徽省宣城县雁翅小学,教师

1990-1991年,安徽安庆石化总厂中学 教师

1991-2000年,江苏省镇江医学院 教师

2001-2003年,美国克利夫兰医院访问学者,复旦大学联合培养博士研究生

2003-2006年,华中科技大学生命科学与技术学院,副教授

2006-现在,华中科技大学生命科学与技术学院,教授,博士生导师

学术兼职

湖北省遗传学会常务理事、医学遗传主任委员,中国动物学会斑马鱼分会理事,中华医学遗传学杂志编委

研究方向

从遗传学、生物化学,以及细胞和发育的角度,认识遗传病发生的分子病理机制,探索新的疾病预防和治疗手段。主要包括:1、遗传病相关基因的克隆,基因和蛋白的生理功能;2、视觉生理和眼科疾病;3、斑马鱼模型和遗传病疾病发生的病理机制研究。招生信息:每年招收硕士研究生、博士研究生和博士后研究人员。


近年的科研项目、专著与论文、专利、获奖

2004年以来,主持(过)国家自然基金8项,主持国家十五科技攻关项目1项,参加国家863项目、科技支撑项目以及973项目。发表学术论文70多篇。

近五年代表性论文

1. Hu X, Lu Z, Yu S, Reilly J, Liu F, Jia D, Qin Y, Han S, Liu X, Qu Z, Lv Y, Li J, Huang Y, Jiang T, Jia H, Wang Q, Liu J, Shu X, Tang Z*, Liu M*. CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. Autophagy. 2019 Mar;15(3):453-465.

2. Yu S, Jiang T, Jia D, Han Y, Liu F, Huang Y, Qu Z, Zhao Y, Tu J, Lv Y, Li J, Hu X, Lu Z, Han S, Qin Y, Liu X, Xie S, Wang QK, Tang Z, Luo D*, Liu M*. BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 2019 Feb 21;133(8):805-815.

3. Han S, Liu X, Xie S, Gao M, Liu F, Yu S, Sun P, Wang C, Archacki S, Lu Z, Hu X, Qin Y, Qu Z, Huang Y, Lv Y, Tu J, Li J, Yimer TA, Jiang T, Tang Z, Luo D*, Chen F, Liu M*. Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy. Hum Genet. 2018 Oct;137(10):779-794

4. Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, Yu S, Lu Z, Han S, Hu X, Qu Z, Liu X, Assefa Yimer T, Yang L, Tang Z, Li DW*, Liu M*. HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death Dis. 2017 Oct 5;8(10):e3082.

5. Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, Liu X, Liu Y, Huang Y, Lu Z, Han S, Wang L, Liu JY, Jiang T, Shu X, Wong F, Tang Z*, Liu M*. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017 Jun 15;26(12):2335-2345.

6. Liu F, Qin Y, Yu S, Soares DC, Yang L, Weng J, Li C, Gao M, Lu Z, Hu X, Liu X, Jiang T, Liu JY, Shu X, Tang Z, Liu M*. Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. J Biol Chem. 2017 Apr 14;292(15):6225-6239.

7. Lu Z, Hu X, Liu F, Soares DC, Liu X, Yu S, Gao M, Han S, Qin Y, Li C, Jiang T, Luo D, Guo AY, Tang Z*, Liu M*. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Sci Rep. 2017 Apr 5;7:46098. doi: 10.1038/srep46098.

8. Liu F, Chen J, Yu S, Raghupathy RK, Liu X, Qin Y, Li C, Huang M, Liao S, Wang J, Zou J, Shu X, Tang Z*, Liu M*. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Hum Mol Genet. 2015 Aug 15;24(16):4648-59.

9. Huang M, Li D, Huang Y, Cui X, Liao S, Wang J, Liu F, Li C, Gao M, Chen J, Tang Z, Li DW*, Liu M*. HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53. Biochim Biophys Acta. 2015 Aug;1850(8):1808-17.

10. Li C, Wang L, Zhang J, Huang M, Wong F, Liu X, Liu F, Cui X, Yang G, Chen J, Liu Y, Wang J, Liao S, Gao M, Hu X, Shu X, Wang Q, Yin Z, Tang Z*, Liu M*. CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014 Jul;1842(7):1121-9.

11. Cai-E Zhang, Duanzhuo Li, Jian-Guo Zhang, Xing-Ping Chen, Mi Huang, Stephen Archacki, Yu-Ke Tian, Wei-Ping Ren, Ai-Hua Mei, Qing-Yan Zhang, Ming-Yan Fang, Zheng Su, Xiukun Cui, Huan-Ming Yang, Qing Wang , Jun Wang, Mugen Liu*, and Yun-Hua Deng*, Mutations in ABCB6 Cause Dyschromatosis Universalis Hereditaria, Journal of Investigative Dermatology. 2013 Sep;133(9):2221-8.

12. Cui X, Wang L, Zhang J, Du R, Liao S, Li D, Li C, Ke T, Li DW, Huang H, Yin Z, Tang Z*, Liu M*. HSF4 Regulates DLAD Expression and Promotes Lens De-nucleation. (BBA) - Molecular Basis of Disease . 2013 Aug;1832(8):1167-72.

13. Liu F, Li P, Liu Y, Li W, Wong F, Du R, Wang L, Li C, Jiang F, Tang Z, Liu M*. Novel compound heterozygous mutations in MYO7A in a Chinese family with Usher syndrome type 1, molecular vision. Mol Vis. 2013;19:695-701. Epub 2013 Mar 21 .

14. Cui X, Zhang J, Du R, Wang L, Archacki S, Zhang Y, Yuan M, Ke T, Li H, Li D, Li C, Li DW, Tang Z, Yin Z*, Liu M*. HSF4 is involved in DNA damage repair through regulation of Rad51. Biochim Biophys Acta. 2012 Aug;1822(8):1308-15.

15. Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ, Cheng X, Li C, Yang R, Wang CC, Wu G, Lu QL, Bai Y, Huang YF, Yin D, Yang Q, Wang XJ, Dai DP, Zhang RF, Wan J, Ji LY, Gao LJ, Li L, Liu H, Huang EW, Cui J, Jia N, Ren X, Li H, Ke T, Zhang XQ, Liu JY, Liu MG, Xia H, Yang B, Shi LS, Xia YL, Tu X, Wang QK. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet. 2011 Mar 6;43(4):345-9.

16. Tang Z, Wang Z, Wang Z, Ke T, Wang QK, Liu M*. Novel compound heterozygous mutations in CERKL cause autosomal recessive retinitis pigmentosa in a nonconsanguineous Chinese family. Arch Ophthalmol. 2009 Aug;127(8):1077-8.

17. Hui Li, Chang li, Qiulun Lu, Su Ting, Tie Ke, Cheng W Li, Mingxiong Yuan, Jingyu Liu, Xiang Ren, Zhihong Zhang, Shaoqiong Zeng, Qing K. Wang, Mugen Liu*. Cataract mutation P20S of aB-crystallin impairs chaperone activity of aA-crystallin and induces apoptosis of human lens epithelial cells. BBA-MOL BASIS DIS. 2008 May;1782(5):303-9.

18. Mugen Liu, Tie Ke, Zhaoxiang Wang, Qinbo Yang, Wei Chang, Fagang Jiang, Zhaohui Tang. Hui Li, Xiang Ren, Xu Wang, Tao Wang, Qingchun Li, Junguo Yang, Jingyu Liu, Qing K Wang. Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family. Invest Ophth Vis Sci. 2006 47(8):3461-3466.

19. Tie Ke, Binchu Ji, Xu Wang, Ping Liu, Xianqin Zhang, Zhaohui Tang, Xiang Ren, Qing k. Wang, Mugen Liu*. Novel HSF4 Mutation Causes Congenital Total White Cataract in a Chinese Family. Am J Ophthalmol. 2006 142(2):298-303.

20. Xiao-Li Tian#, Rajkumar Kadaba#, Sun-Ah You#, Mugen Liu#, Ayse Anil Timur, Lin Yang, Qiuyun Chen, Przemyslaw Szafranski, Shaoqi Rao, Ling Wu, David E. Housman, Paul E. DiCorleto, David J. Driscol, Julian Borrow and Qing Wang. 2004.Positional cloning of an angiogenic factor gene: VG5Q mutations cause susceptibility to Klippel-Trenaunay syndrome; Nature 427(6975):640-5(#co-first authors).




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