Tian Wei


Phone: 00

Email: tianwei@hust.edu.cn

Academic Areas: Biophysics

Research Interests: 1 . The chromosome KinetochoreKinetochore and mitotic checkpoint in the regulation of cell mitosis ; 2 . The cellproliferation of cancer signaling pathways Hippo pathway of upstream and downstreamsignal transduction and regulation mechanism

Academic Degrees

Ph.D. in Biophysics

Professional Experience

Sep2008 ~Feb 2014           Postdoctoral Researcher   

UT Southwestern Medical Center, US


Feb 2014~PRESENT         Professor;Principal Investigator

School of Life Science and Technology,

Huazhong University of Science and Technology, Wuhan,China


Selected Publications

1. The Cdc20-binding Phe box of BubR1 promotes MCC formation during mitosis

Díaz-Martínez LA#, Tian W#, Li B, Warrington Ross, Jia L, Luo X*, Yu H*;

J Biol Chem. 2015 Jan 23; 290(4):2431-43. (#equal contribution)


2. Synergistic Blockade of Mitotic Exit by Two Chemical Inhibitors of the APC/C.

Sackton KL#, Dimova N#, Zeng X#, Tian W#, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW*;

Nature. 2014 Oct 30; 514(7524):646-9. (#equal contribution)


3. Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

Tian W#, Li B#, Warrington R, Tomchick DR, Yu H*, Luo X*;

Proc Natl Acad Sci U S A. 2012 Nov 6; 109(45):18419-24. (#equal contribution)


4. Structural and functional analysis of the YAP-binding domain of human TEAD2.

Tian W, Yu J, Tomchick DR, Pan D*, Luo X*;

Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7293-8.


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