Chen Liming


Phone: 027-87794006


Academic Areas: Physiology and Biophysics of Acid-Base Transport

Research Interests: Structure and function, mechanism underlying the functional regulation, the physiology and pathology of acid-base transporters.

Academic Degrees

1997−2002, Ph.D., School of Life Sciences, Peking University

1993−1997, B.S., School of Life Sciences, Peking University

Professional Experience

2015−present: Professor, School of Life Sciences and Technology, HUST

2008−2015: Associate Professor, School of Life Sciences and Technology, HUST

2008−2009: Instructor, Department of Biophysics and Physiology, School of Medicine, Case Western Reserve University

2007−2008: Senior Research Associate, Department of Biophysics and Physiology, School of Medicine, Case Western Reserve University

2003−2007: Postdoctoral Associate, Department of Cellular and Molecular Physiology, School of Medicine, Yale University

2002−2003, Postdoc, School of Medicine, New York University

Selected Publications

  1. Yi-Min Guo#, Ying Liu#, Mei Liu, Jin-Lin Wang, Zhang-Dong Xie, Kang-Jing Chen, Deng-Ke Wang, Rossana Occipinti, Walter F. Boron, Li-Ming Chen*. Na+/HCO3 cotransporter NBCn2 mediates HCO3 reclamation in the apical membrane of renal proximal tubules. Journal of the American Society of Nephrology. Online on March 9th, 2017. (#equal contribution). (Highlighted by Nature Review Nephrology).
  2. Weili Yang, Junpei Wang, Zhenzhen Chen, Ji Chen, Yuhong Meng, Liming Chen, Yongsheng Chang, Bin Geng, Libo Sun, Lin Dou, Jian Li, Youfei Guan, Qinghua Cui and Jichun Yang. NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing Hepatic FAM3A-ATP-Akt Pathway. Diabetes. April 14th, 2017.
  3. Zhenzhen Chen, Liwei Ding, Weili Yang, Junpei Wang, Liming Chen, Yongsheng Chang, Bin Geng, Qinghua Cui, Youfei Guan, Jichun Yang. Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice. Diabetes. Feb 27th, 2017.
  4. Ying Liu, Xiao-Yu Wang, Zhang-Dong Xie, Li-Ming Chen*. Na+/HCO3 cotransporter NBCn1. Encyclopedia of Signaling Molecules, 2nd Edition. Edited by Sangdun Choi, Springer, Nov. 28th, 2016. ISBN: 978-1-4614-6438-9 (Invited chapter)
  5. Li-Ming Chen, Mei Liu, Ying Liu*. Electrophysiology principles of Na+/HCO3 cotransporters. Acta Physiologica Sinica. 2016, 68(3): 323-334.
  6. Ying Liu, Jichun Yang, Li-Ming Chen*. Structure and Function of SLC4 family HCO3 transporters. Frontiers in Physiology. 2015, 6:355.
  7. Deng-Ke Wang§, Ying Liu§, Evan J. Myers, Yi-Min Guo, Zhang-Dong Xie, De-Zhi Jiang, Jia-Min Li, Jichun Yang, Mugen Liu, Mark D. Parker, Li-Ming Chen*. Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na+/HCO3 cotransporters. Scientific Reports. 2015. 5: 12241, p.1−23. doi: 10.1038/srep12241. (§ Co-first author)
  8. Ying Liu, Li-Ming Chen*. Towards bridging the gap between acid-base transporters and neuronal excitability modulation. International Journal of Physiology, Pathophysiology & Pharmacology. Invited Editorial. 2014; 6(4): 221-225.
  9. Yi-Min Guo, Ying Liu, Li-Ming Chen*. HCO3 reabsorption in proximal renal tubule: molecular mechanism and metabolic acidosis. Acta Physiologica Sinica. 2014 Aug 25;66(4):398-414b.
  10. Ying Liu, Xue Qin, Deng-Ke Wang, Yi-Min Guo, Harindarpal S. Gill, Nathan Morris, Mark D. Parker, Li-Ming Chen*, Walter F. Boron. Effects of optional structural elements, including two alternative amino termini and a new splicing cassette IV, on the function of NBCn1 (SLC4A7). The Journal of Physiology-London. 2013, 591(Pt 20):4983-5004.
  11. Ying Liu, Deng-Ke Wang, De-Zhi Jiang, Xue Qin, Zhang-Dong Xie, Qing K. Wang, Mugen Liu, Li-Ming Chen*. Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of Slc4a10. PLoS ONE 2013; 8(2):e55974.
  12. Ying Liu, Qun-Wei Lu, Li-Ming Chen*. Physiology and pathophysiology of Na/HCO3 cotransporter NBCe1. Acta Physiologica Sinica. 2012, 62(6):729-740. (Review. Journal cover)
  13. Li-Ming Chen*, Xue Qin, Fraser J. Moss, Ying Liu, Walter F. Boron*. Effect of simultaneously replacing putative TM6 and TM12 of human NBCe1-A with those from NBCn1 on surface abundance in Xenopus oocytes. Journal of Membrane Biology. 2012, 245(3): 131-40.
  14. Ying Liu, Deng-Ke Wang, Li-Ming Chen*. The physiology of bicarbonate transporters in mammalian reproduction. Biology of Reproduction. 2012, 86(4):99, 1-13.
  15. Ying Liu, Jiu-Ying Xu, Deng-Ke Wang, Lei Wang, Li-Ming Chen*. Cloning and identification of two novel NBCe1 splice variants from mouse reproductive tract tissues: A comparative study of NCBT genes. Genomics. 2011, 98:112-119.
  16. Ying Liu, Jiu-Ying Xu, Deng-Ke Wang, Walter F. Boron, Li-Ming Chen*. Expression and distribution of NBCn2 (Slc4a10) splice variants in mouse brain: cloning of novel variant NBCn2-D. Brain Research, 2011, 1390:33-40.
  17. Li-Ming Chen*, Ying Liu, Walter F. Boron. Role of an extracellular loop in determining the stoichiometry of Na/HCO3 cotransporters. The Journal of Physiology-London, 2011, 589(4) 877-890.
  18. Li-Ming Chen, Jinhua Zhao, Raif Musa-Aziz, Marc Pelletier, Ian A Drummond, Walter F Boron. Cloning and Characterization of a zebrafish cDNA homologue of human AQP1: A bifunctional water and gas channel. Am J Physiol Regul Integr Comp Physiol 2010, 299(5):R1163-74.
  19. Ying Liu, Kui Xu, Li-Ming Chen, Xiuyan Sun, Mark D Parker, Michelle L Kelly, Joseph C LaManna, Walter F Boron. Distribution of NBCn2 (SLC4A10) splice variants in mouse brain. Neuroscience, 2010, 169(3):951-964.
  20. Raif Musa-Aziz, Lihong Jiang, Li-Ming Chen, KevineL Behar, Walter F Boron. Concentration-dependent effects on intracellular and surface pH of exposing Xenopus oocytes to solutions containing NH3/NH4+. Journal of Membrane Biology. 2009, 228(1):15-31.
  21. Walter F. Boron, Liming Chen, Mark D. Parker. Modular Structure of Sodium-Coupled Bicarbonate Transporters. The Journal of Experimental Biology. 2009, 212:1697-1706. (Invited Review).
  22. Raif Musa-Aziz#, Li-Ming Chen#, Marc F Pelletier, Walter F Boron. Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Proc Natl Acad Sci USA, 2009, 106(13):5406-5411. (#Co-first author).
  23. Li-Ming Chen*, Gabriel G Haddad, Walter F Boron. Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain. Brain Research. 2008, 1238:85-92.
  24. L-M Chen*, ML Kelly, MD Parker, HS Gill, JM Felie, BA Davis, WF Boron*. Expression and localization of Na+-driven Cl-HCO3 exchanger (SLC4A8) in rodent CNS. Neuroscience. 2008, 153(1):162-174.
  25. Li-Ming Chen*, Michelle L Kelly, Jose D Rojas, Mark D Parker, Harindarpal S Gill, Bruce A Davis, Walter F Boron. Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain. Neuroscience. 2008, 151(2):374-385.
  26. Li-Ming Chen*, Inyeong Choi, Gabriel G Haddad, Walter F Boron. Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol. 2007, 293(6):R2412-20.
  27. Volker Endeward, Raif Musa-Aziz, Gordon J Cooper, Li-Ming Chen, Marc F Pelletier, Leila V Virkki, Claudiu T Supuran, Landon S King, Walter F Boron, Gerolf Gros. Evidence that aquaporin 1 is the major pathway for CO2 transport across the human erythrocyte membrane. FASEB Journal, 2006, 20:1974-1981.
  28. Li-Ming Chen, Xing-Wen Yang, and Jian-Guo Tang. Expression of human prorelaxin H2 in Eschericia coli, protein purification and characterization. Acta Biochimica et Biophysica Sinica. 2002, 34(5)595-600.
  29. Li-Ming Chen, Xing-Wen Yang, and Jian-Guo Tang. Acidic residues on the N-terminus of proinsulin C-peptide are important for the folding of insulin precursor. Journal of Biochemistry (Tokyo), 2002, 131(6):855-859.

Courses Taught

0700991  Biophysics for undergraduate students

0707291  Literature Reading and Academic Writing

170.550  Cellular Electrophysiology for graduate students

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