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Engineering to Form Biological Structures and to Attack Cancer

time:2019-12-02 09:23     number of views:

报告题目:Engineering  to   Form  Biological  Structures  and  to  Attack  Cancer

报告人: 黄建东 香港大学“明德”讲座教授



邀请人:王晨辉 罗亮

黄建东教授于1988年在复旦大学获得学士学位,随后通过中美生化联合考试项目(CUSBEA)进入美国加州大学洛杉矶分校进行果蝇胚胎转录和生物图形形成的研究,并在1994年获得理学博士(PhD)学位。1994到1998年在美国国家健康研究院(NIH)和国立癌症研究所(NCI)进行博士后研究,师从美国科学院Neal G. Copeland 院士和Nancy A. Jenkins 院士。1998年,黄教授加入香港大学,现为香港大学生物医学学院“明德”冠名正教授,粤港澳大湾区转化医学联盟副主任。黄教授的工作集中于DNA重组工程学(recombineering)。他提供了解释高效DNA重组机理的实验证据,提高了DNA重组工程学在大肠杆菌和哺乳细胞的效率,并将这项技术用于基因组学的研究。他从2008年开始了合成生物学的研究,主要致力于编码细胞合成人工生物结构,并将人工编码的细胞用于生物医学的研究与开发,如疫苗开发、癌症治疗等。

Abstract: The genomic era started with the Genome Projects ofvarious model organisms, including humans, conferring the humarace the ability to "read" genomes for its stored information. When the reading technology reaches its full capacity, the next phase of genome research should be ready to embark on the design (a.k.a., writing) of new genomes. The synthesis of designed genomes will create new life forms and will allow a true advance of genomics to the stage of biotechnological applications that generate bioproducts of energy, environment, andhealthcare relevance. In this presentation, Dr. Huang will discuss his work on designing and engineering bacteria to revealthe principle underlying biological pattern formation and to target tumors.