报告题目：Plasma membrane repair by a calcium-activated phospholipid scramblase

报告人： 武宁，博士，教授

报告时间：2019年12月12日（周四）12:50-14:00

报告地点：生科院二楼221大会议室

邀请人：王晨辉 教授

武宁，博士，教授

华中科技大学同济医学院免疫系

武汉，湖北

电子邮件: wun@hust.edu.cn

电话：18627106755

学习工作经历

2017/9～ 教授，博士生导师，华中学者特聘教授，华中科技大学同济医学院免疫学系

2015/11～2017/9 助理研究员，分子肿瘤实验室，蒙特利尔临床医学研究所, 蒙特利尔，加拿大

2010/10～2015/10 博士后，蒙特利尔临床医学研究所, 蒙特利尔，加拿大

2006－2010 博士学位：分子与细胞生物学,法国原子能研究所，功能基因组／生物芯片实验室

2004－2006 工程师学位，巴黎格力农农业学院(INAPG), 法国

硕士学位：发育生物学； 巴黎五大，巴黎七大，巴黎八大，INAPG 和国立兽医学院

联合专业,

荣誉:

2012～2015 加拿大魁北克健康研究基金奖学金

2004～2010 法国医学研究基金奖学金、法国原子能研究所奖学金、法国外交部埃菲尔奖学金

主要发表文献

1. Wu, N., Zhong, M.C., Roncagalli, R., Perez-Quintero, L.A., Guo, H., Zhang, Z., Lenoir, C., Dong, Z.,Latour, S., and Veillette, A. (2016). A hematopoietic cell-driven mechanism involving SLAMF6 receptor,SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nature immunology 17, 387-396.

2. Wu, N.*, and Veillette, A.* (2016). SLAM family receptors in normal immunity and immune pathologies.Current opinion in immunology 38, 45-51. *Co-corresponding authors

3. Wu, N., and Veillette, A. (2011). Immunology: Magnesium in a signalling role. Nature 475, 462-463.

4. Wu, N., Castel, D., Debily, M.A., Vigano, M.A., Alibert, O., Mantovani, R., Iljin, K., Romeo, P.H., and Gidrol, X. (2011). Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. The Journal of biological chemistry 286, 20870-20879.

5. Wu, N.*, and Gidrol, X.* (2014). The wind rose of human keratinocyte cell fate. Cellular and molecular life sciences : CMLS 71, 4697-4702. *Co-corresponding authors

6. Wu, N., Rollin, J., Masse, I., Lamartine, J., and Gidrol, X. (2012). p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. The Journal of biological chemistry 287, 5627-5638.

7. Wu, N., Sulpice, E., Obeid, P., Benzina, S., Kermarrec, F., Combe, S., and Gidrol, X. (2012). The miR-17 family links p63 protein to MAPK signaling to promote the onset of human keratinocyte differentiation. PloS one 7, e45761.

8. Gavino, C., Landekic, M., Zeng, J., Wu, N., Jung, S., Zhong, M.C., Cohen-Blanchet, A., Langelier, M.,Neyret, O., Lejtenyi, D., Rochefort, C., Cotton-Montpetit, J., McCusker, C., Mazer, B., Veillette, A., and Vinh, D.C. (2017). Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency. J Allergy Clin Immunol 139, 1688-1692 e1610.

9. Chen, J., Zhong, M.C., Guo, H., Davidson, D., Mishel, S., Lu, Y., Rhee, I., Perez-Quintero, L.A., Zhang,S., Cruz-Munoz, M.E., Wu, N., Vinh, D.C., Sinha, M., Calderon, V., Lowell, C.A., Danska, J.S., and Veillette, A. (2017). SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1integrin. Nature 544, 493-497.

10. Guo, H., Cranert, S.A., Lu, Y., Zhong, M.C., Zhang, S., Chen, J., Li, R., Mahl, S.E., Wu, N., Davidson,D., Waggoner, S.N., and Veillette, A. (2016). Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. The Journal of experimental medicine 213, 2187-2207.

11. Zhang, Z., Wu, N., Lu, Y., Davidson, D., Colonna, M., and Veillette, A. (2015). DNAM-1 controls NK cell activation via an ITT-like motif. The Journal of experimental medicine 212, 2165-2182.

12. Guo, H., Cruz-Munoz, M.E., Wu, N., Robbins, M., and Veillette, A. (2015). Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells. Molecular and cellular biology 35, 41-51.

13. Li, J., Davidson, D., Martins Souza, C., Zhong, M.C., Wu, N., Park, M., Muller, W.J., and Veillette, A.(2015). Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition. Molecular and cellular biology 35, 4069-4082.

14. Murn, J., Alibert, O., Wu, N., Tendil, S., and Gidrol, X. (2008). Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. The Journal of experimental medicine 205, 3091-3103.

15. Thoby-Brisson, M., Karlen, M., Wu, N., Charnay, P., Champagnat, J., and Fortin, G. (2009). Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex. Nature neuroscience 12, 1028-1035.

16. Benzina, S., Pitaval, A., Lemercier, C., Lustremant, C., Frouin, V., Wu, N., Papine, A., Soussaline, F.,Romeo, P.H., and Gidrol, X. (2015). A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cellular and molecular life sciences : CMLS.

17. Gidrol, X., Wu, N., Frouin, V., and Debily, M.A. (2008). [Inference of transcriptional regulatory networks]. Medecine sciences : M/S 24, 629-634.

主要科研项目：

1. 国自然重点，免疫调节性生物材料诱导心脏瓣膜原位再生的机制研究（81930052），2020-2024，参与；

2. 国自然面上，跨膜蛋白 16F 在免疫细胞信号传导中的作用及其机制研究（31870863），2019-2022，主持；