报告题目: 化学交联质谱在生物研究领域的应用

报告人  : Dr. Juan Zou，University of Edinburgh

报告时间: 2019年6月10日9:30-11:00

报告地点:生科院四楼会议室

邀请人  :杨祥良 教授

专家简介：

Employment

2009 – Present: Proteomics data analysis manager, Wellcome Trust Centre for Cell Biology (WCB), the University of Edinburgh

2007 – 2009 Study Director, Concept Life Science, Dundee, UK

2000 – 2007: Research Fellow/ Senior Research Fellow, Renal Autoimmunity Group (RAG), Queen’s Medical Research Institute, the University of Edinburgh, UK

1998 – 2000: Wellcome Trust International Travelling Research Fellow

1996 – 1998: Postdoctoral Researcher, College of Chemistry and Molecular Engineering, the Peking University, Beijing, China

Qualifications and Awards：

September 2005 – September 2007 (part time) M. Sc.in bioinformatics, School of informatics, the University of Edinburgh

June 1993 – April 1996 Ph.D Medicinal chemistry, School of Pharmaceutical Science, the Peking University and Nanjing University (joint programme).

Thesis: Synthesis, characterization, antitumor activity and toxicity studies of new cisplatin analogues

Award: Progressive Scholarship in Science and Technology of China (with Prof. Kui Wang, supervisor)

摘要：

化学交联质谱是通过化学交联剂将蛋白质复合物之间或蛋白质分子内近距离的氨基酸残基以共价键的方式连接在一起。通过蛋白酶解，用质谱鉴定交联位点，从而演绎蛋白质复合物中分子之间的相对空间位置，分子内的折叠及构象变化。这一讲座将通过实例，展示交联质谱技术的实际应用以及新的发展趋势。