“生物医用共轭高分子材料”科研团队隶属于华中科技大学生命科学与技术学院纳米药物与生物制药系，依托于国家纳米药物工程技术研究中心、教育部分子生物物理重点实验室和生物无机化学与药物湖北省重点实验室，长期致力于共轭高分子材料的合成及在医学影像、生物检测、药物递送等方面的应用研究。近5年发表SCI论文30余篇，授权相关发明专利10余件；团队包括博士后3人，在读博士生7人，在读硕士生7人。出站博士后以及毕业研究生均入职“双一流”高校及国内知名生物制药企业。
团队负责人：罗亮教授
南开大学学士、硕士
美国纽约州立大学石溪分校 博士
美国明尼苏达大学 博士后
国家高层次青年人才
国侨办重点华人华侨创业团队负责人
武汉“3551光谷创新人才计划”
美国中美医药开发协会康涅狄格州分会会长（2016）
国家药品监督管理局药用辅料工程技术研究重点实验室学术委员会委员
中国化学会分子聚集发光专业委员会委员
中国抗癌协会纳米肿瘤学专业委员会常务委员
中国生物物理学会材料生物学与智能诊疗技术分会副秘书长
中国侨商投资企业协会科技创新委员会委员
《Bioengineering》期刊副主编
《Chinese Chemical Letters》期刊青年编委
《纳米生物医学工程》期刊编委会委员
团队成员：
孟凡玲副教授
南开大学 硕士
美国纽约州立大学石溪分校 博士
美国伦斯里尔理工学院 博士后
田斯丹讲师
中国科技大学 学士、博士
华中科技大学 博士后
承担项目
科技部国家重点研发计划
² “微环境响应型自组装生物纳米材料的表/界面调控及肿瘤治疗研究”课题三“自组装生物纳米材料调控肿瘤血管及肿瘤治疗研究”
国家自然科学基金
² “共轭聚合物拉曼探针及其在高分辨多色拉曼成像中的应用”面上项目；
² “基于多阳离子“自报告”光敏剂的单分子肿瘤光动力诊疗体系研究”面上项目；
² “抑制胰岛淀粉样多肽纤维化的单区抗体的构建及其作用机制”青年科学基金项目；
² “基于超强拉曼散射聚丁二炔衍生物的生物标志物定量检测平台” 青年科学基金项目；
² “具有聚集诱导发光效应的双光子吸收材料在纳米药物方面的研究” 青年科学基金项目。
湖北省自然科学基金
² “拓扑效应对淀粉样蛋白聚集抑制剂功效调节作用的研究” 面上项目
近5年发表论文
² Zhao, L.; Wang, S.; Hu, Q.; Jia, H.; Xin, Y.; Luo, L.; Meng, F., Conformation-reconstructed multivalent antibody mimic for amplified mitigation of human islet amyloid polypeptide amyloidogenesis. Nanoscale 2022, 14 (7), 2802-2815.
² Zhuang, Z.; Meng, F.; Luo, L., Naked-eye detection and sustainable removal of zinc ions in water by a conjugated polymer with ratiometric absorption. Organic Electronics 2021, 99,106347:1-6.
² He, Z.; Gao, Y.; Zhang, H.; Xue, Y.; Meng, F.; Luo, L., Mitochondrion-Anchored Photosensitizer with Near Infrared-I Aggregation-Induced Emission for Near Infrared-II Two-Photon Photodynamic Therapy. Adv Healthc Mater 2021, e2101056:1-10.
² Xin, Y.; Wang, S.; Liu, H.; Ke, H.; Tian, S.; Cao, Y.; Huang, Y.; Shang, Y.; Jia, H.; Su, L.; Yang, X.; Meng, F.; Luo, L., Hierarchical Vitalization of Oligotyrosine in Mitigating Islet Amyloid Polypeptide Amyloidogenesis through Multivalent Macromolecules with Conformation-Restrained Nanobody Ligands. Acs Nano 2021,15,13319-13328.
² Yue, Q.; He, X.; Yan, N.; Tian, S.; Liu, C.; Wang, W.-X.; Luo, L.; Tang, B. Z., Photodynamic control of harmful algal blooms by an ultra-efficient and degradable AIEgen-based photosensitizer. Chemical Engineering Journal 2021, 417,127890:1-11.
² Tian, S.; Yue, Q.; Liu, C.; Li, M.; Yin, M.; Gao, Y.; Meng, F.; Tang, B. Z.; Luo, L., Complete Degradation of a Conjugated Polymer into Green Upcycling Products by Sunlight in Air. J Am Chem Soc 2021, 143 (27), 10054-10058.
² Wang, X.; Li, H.; Meng, F.; Luo, L., Bioadhesive metal-phenolic nanoparticles for enhanced NIR imaging-guided locoregional photothermal/antiangiogenic therapy. J Mater Chem B 2021, 9 (23), 4710-4717.
² Huang, L.; Zhang, Y.; Li, Y.; Meng, F.; Li, H.; Zhang, H.; Tu, J.; Sun, C.; Luo, L., Time-Programmed Delivery of Sorafenib and Anti-CD47 Antibody via a Double-Layer-Gel Matrix for Postsurgical Treatment of Breast Cancer. Nanomicro Lett 2021, 13 (1), 141:1-15.
² He, Z.; Tian, S.; Gao, Y.; Meng, F.; Luo, L., Luminescent AIE Dots for Anticancer Photodynamic Therapy. Front Chem 2021, 9, 672917:1-13.
² Xue, Y.; Gao, Y.; Meng, F.; Luo, L., Recent progress of nanotechnology-based theranostic systems in cancer treatments. Cancer Biol Med 2021,18(2),336-351.
² Cao, Y.; He, Z.; Gao, Y.; Xin, Y.; Luo, L.; Meng, F., Boosting the Photodynamic Degradation of Islet Amyloid Polypeptide Aggregates Via a "Bait-Hook-Devastate" Strategy. ACS Appl Mater Interfaces 2021, 13(13),14911-14919.
² Fang, F.; Gao, Y.; Luo, L., Mitochondrion-anchoring AIEgen with Large Stokes Shift for Imaging-guided Photodynamic Therapy. Chemical Research in Chinese Universities 2021, 37 (1), 137-142.
² Liu, C.; Wang, X.; Liu, J.; Yue, Q.; Chen, S.; Lam, J. W. Y.; Luo, L.; Tang, B. Z., Near-Infrared AIE Dots with Chemiluminescence for Deep-Tissue Imaging. Adv Mater 2020, e2004685：1-6.
² Nie, C.; Zhang, B.; Gao, Y.; Yin, M.; Yi, X.; Zhao, C.; Zhang, Y.; Luo, L.; Wang, S., Thickness-Dependent Enhancement of Electronic Mobility of MoS2 Transistors via Surface Functionalization. The Journal of Physical Chemistry C 2020, 124 (31), 16943-16950.
² He, Z.; Gao, Y.; Zhang, H.; Wang, X.; Meng, F.; Luo, L.; Tang, B. Z., Platinum-AIEgen coordination complex for imaging-guided annihilation of cisplatin-resistant cancer cells. Chem Commun (Camb) 2020, 56 (56), 7785-7788.
² Gao, Y.; Zhang, H.; He, Z.; Fang, F.; Wang, C.; Zeng, K.; Gao, S.; Meng, F.; Luo, L.; Tang, B. Z., Multicationic AIEgens for unimolecular photodynamic theranostics and two-photon fluorescence bioimaging. Materials Chemistry Frontiers 2020, 4 (6), 1623-1633.
² Hou, Y.; Kurganskii, I.; Elmali, A.; Zhang, H.; Gao, Y.; Lv, L.; Zhao, J.; Karatay, A.; Luo, L.; Fedin, M., Electronic coupling and spin-orbit charge transfer intersystem crossing (SOCT-ISC) in compact BDP-carbazole dyads with different mutual orientations of the electron donor and acceptor. J Chem Phys 2020, 152 (11), 114701.
² Wang, X.; Huang, L.; Zhang, Y.; Meng, F.; Donoso, M.; Haskell, R.; Luo, L., Tunable Two-Compartment On-Demand Sustained Drug Release Based on Lipid Gels. J Pharm Sci 2020, 109 (2), 1059-1067.
² Fang, F.; Meng, F.; Luo, L., Recent advances on polydiacetylene-based smart materials for biomedical applications. Materials Chemistry Frontiers 2020, 4 (4), 1089-1104.
² Wang, Z.; Ivanov, M.; Gao, Y.; Bussotti, L.; Foggi, P.; Zhang, H.; Russo, N.; Dick, B.; Zhao, J.; Di Donato, M.; Mazzone, G.; Luo, L.; Fedin, M., Spin-Orbit Charge-Transfer Intersystem Crossing (ISC) in Compact Electron Donor-Acceptor Dyads: ISC Mechanism and Application as Novel and Potent Photodynamic Therapy Reagents. Chemistry 2020, 26 (5), 1091-1102.
² Wang, X.; Tong, J.; He, Z.; Yang, X.; Meng, F.; Liang, H.; Zhang, X.; Luo, L., Paclitaxel-Potentiated Photodynamic Theranostics for Synergistic Tumor Ablation and Precise Anticancer Efficacy Monitoring. ACS Appl Mater Interfaces 2020, 12 (5), 5476-5487.
² Tian, S.; Li, H.; Li, Z.; Tang, H.; Yin, M.; Chen, Y.; Wang, S.; Gao, Y.; Yang, X.; Meng, F.; Lauher, J. W.; Wang, P.; Luo, L., Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging. Nature Communications 2020, 11 (1), 81:1-9.
² Gao, Y.; He, Z.; He, X.; Zhang, H.; Weng, J.; Yang, X.; Meng, F.; Luo, L.; Tang, B. Z., Dual-Color Emissive AIEgen for Specific and Label-Free Double-Stranded DNA Recognition and Single-Nucleotide Polymorphisms Detection. J Am Chem Soc 2019, 141 (51), 20097-20106.
² Huang, L.; Li, Y.; Du, Y.; Zhang, Y.; Wang, X.; Ding, Y.; Yang, X.; Meng, F.; Tu, J.; Luo, L.; Sun, C., Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy. Nat Commun 2019, 10 (1), 4871.
² DeCicco, R. C.; Luo, L.; Goroff, N. S., Exploiting Unsaturated Carbon-Iodine Compounds for the Preparation of Carbon-Rich Materials. Acc Chem Res 2019, 52 (8), 2080-2089.
² He, X.; Xiong, L. H.; Zhao, Z.; Wang, Z.; Luo, L.; Lam, J. W. Y.; Kwok, R. T. K.; Tang, B. Z., AIE-based theranostic systems for detection and killing of pathogens. Theranostics 2019, 9 (11), 3223-3248.
² Gao, Y.; Wang, X.; He, X.; He, Z.; Yang, X.; Tian, S.; Meng, F.; Ding, D.; Luo, L.; Tang, B. Z., A Dual‐Functional Photosensitizer for Ultraefficient Photodynamic Therapy and Synchronous Anticancer Efficacy Monitoring. Advanced Functional Materials 2019, 29 (32),1902673.
² Zhao, L.; Xin, Y.; Li, Y.; Yang, X.; Luo, L.; Meng, F., Ultraeffective Inhibition of Amyloid Fibril Assembly by Nanobody–Gold Nanoparticle Conjugates. Bioconjugate Chem 2019, 30 (1), 29-33.
² Xin, Y.; Zhang, H.; Hu, Q.; Tian, S.; Wang, C.; Luo, L.; Meng, F., Oligotyrosines Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in a Tyrosine-Number-Dependent Manner. Acs Biomater Sci Eng 2019, 5 (2), 1092-1099.
² Wang, Z.; Gao, Y.; Hussain, M.; Kundu, S.; Rane, V.; Hayvali, M.; Yildiz, E. A.; Zhao, J.; Yaglioglu, H. G.; Das, R.; Luo, L.; Li, J., Efficient Radical-Enhanced Intersystem Crossing in an NDI-TEMPO Dyad: Photophysics, Electron Spin Polarization, and Application in Photodynamic Therapy. Chemistry – A European Journal 2018, 24 (70), 18663-18675.
² Xin, Y.; Wang, X.; Luo, L.; Meng, F., Conformation-Dependent Manipulation of Human Islet Amyloid Polypeptide Fibrillation by Shiitake-Derived Lentinan. ACS Appl Mater Interfaces 2018, 10 (37), 31069-31079.
² Xin, Y.; Yin, M.; Zhao, L.; Meng, F.; Luo, L., Recent progress on nanoparticle-based drug delivery systems for cancer therapy. Cancer Biol Med 2017, 14 (3), 228-241.
