Postdoctoral Research Fellow and PhD positions are open in Laboratory of Neural Stem cells at Duke-NUS Graduate Medical School Singapore

Fruit fly Drosophila neural stem cells, larval brain neuroblasts, has recently emerged as an excellent model for the study of stem cell self-renewal and tumorigenesis. The balance between self-renewal and differentiation are achieved by asymmetric division of neuroblasts, Drosophila neural stem cells. Defects in asymmetric cell division can results in the imbalance that leads to brain tumor formation. We are interested in studying the molecular mechanism of asymmetric division of neuroblasts and the balance of self-renewal and differentiation. We use a combination of genetics, cell biology and biochemical approaches to study the functions of critical brain tumor suppressors. Our research is exciting and pioneering in the field of asymmetric cell division. The lab environment is stimulating and encouraging. The lab website is as follow:
Website: http://www.duke-nus.edu.sg/web/research/faculty/wang-hongyan

Postdoc applicants should be PhD holders, highly motivated individuals and have a research background in cell Biology, developmental biology or Biochemistry. Previous experience with Drosophila genetics is desirable. The applicants should have at least one first-author publication in a good international journal during PhD training.

PhD applicants are open to those who have obtained a B. S or M. S from a renowned university, and have taken GRE and TOFEL.

CV and 3 reference letters should be sent to Dr. Hongyan Wang at hongyan.wang@duke-nus.edu.sg

联系人：Wang, Hongyan, Ph.D.
Assistant Professor, Duke-NUS Graduate Medical School Singapore
8 College Road

Singapore 169857
Phone:  +65 6516 7740
Fax:    +65 6557 0729
E-Mail: hongyan.wang@duke-nus.edu.sg

Website: http://www.duke-nus.edu.sg/web/research/faculty/wang-hongyan

Representative publications:

Chang KC, et al., and Wang H. Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-renewal. (2010) Developmental Cell, 19, 778-85.

Wang C, et al., and Wang H. Protein Phosphatase 2A regulates self-renewal of Drosophila neural stem cells. (2009) Development 136, 2287-96.

Wang H, et al.,. Polo inhibits neural progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature 449, 96-100 (2007)

Wang H, et al., Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes and Development, 20:3453-63 (2006).

Wang H, et al.,. RIC-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nature Cell Biology 7:1091-1098 (2005).

有意者请直接联系Hongyan Wang 或先联系limaoteng426@163.com