人类疾病都有遗传基础，揭示遗传病发病的遗传基础、解析致病基因的功能是阐明疾病发病病理机制、发展疾病预防和治疗手段的关键。视觉科学与医学遗传学科研团队拥有教授1人（刘木根）、正高级高级工程师1人（唐朝晖）、副教授2人（蒋涛、任翔），博士后和博士硕士研究生十几人。课题组承担科技部国家重点研发计划、国家科技支撑计划、973、863，国家自然科学基金项目等课题，在Nature, Blood, Nucleic Acids Res., Autophagy, Hum Mol Genet, J Biol Chem, Cell Death Dis.等学术刊物发表80多篇学术论文。
主要研究方向：
1、遗传病致病基因的克隆和病理机制；
2、斑马鱼疾病模型和眼科遗传病的预防和治疗；
3、胚胎早期发育生物学。
近年来发表的代表性论著：
Liu F, Qin Y, Huang Y, Gao P, Li J, Yu S, Jia D, Chen X, Lv Y, Tu J, Sun K, Han Y, Reilly J, Shu X, Lu Q, Tang Z, Xu C, Luo D, Liu M. Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genet. 2022 Mar 4;18(3):e1009841.
Li J, Liu F, Lv Y, Sun K, Zhao Y, Reilly J, Zhang Y, Tu J, Yu S, Liu X, Qin Y, Huang Y, Gao P, Jia D, Chen X, Han Y, Shu X, Luo D, Tang Z, Liu M. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic Acids Res. 2021 Feb 26;49(4):2027-2043.
Tu J, Liu X, Jia H, Reilly J, Yu S, Cai C, Liu F, Lv Y, Huang Y, Lu Z, Han S, Jiang T, Shu X, Wu X, Tang Z, Lu Q, Liu M. The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB J. 2020 Sep;34(9):11997-12008.
Yu S, Jiang T, Jia D, Han Y, Liu F, Huang Y, Qu Z, Zhao Y, Tu J, Lv Y, Li J, Hu X, Lu Z, Han S, Qin Y, Liu X, Xie S, Wang QK, Tang Z, Luo D, Liu M. BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 2019 Feb 21;133(8):805-815
Hu X, Lu Z, Yu S, Reilly J, Liu F, Jia D, Qin Y, Han S, Liu X, Qu Z, Lv Y, Li J, Huang Y, Jiang T, Jia H, Wang Q, Liu J, Shu X, Tang Z, Liu M. CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. Autophagy. 2019 Mar;15(3):453-465.
Lu Z, Hu X, Reilly J, Jia D, Liu F, Yu S, Liu X, Xie S, Qu Z, Qin Y, Huang Y, Lv Y, Li J, Gao P, Wong F, Shu X, Tang Z, Liu M. Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degeneration. J Biol Chem. 2019 Sep 20;294(38):13953-13963
Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, Yu S, Lu Z, Han S, Hu X, Qu Z, Liu X, Assefa Yimer T, Yang L, Tang Z, Li DW, Liu M. HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators. Cell Death Dis. 2017 Oct 5;8(10):e3082.
Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, Liu X, Liu Y, Huang Y, Lu Z, Han S, Wang L, Liu JY, Jiang T, Shu X, Wong F, Tang Z, Liu M. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017 Jun 15;26(12):2335-2345.
Liu F, Qin Y, Yu S, Soares DC, Yang L, Weng J, Li C, Gao M, Lu Z, Hu X, Liu X, Jiang T, Liu JY, Shu X, Tang Z, Liu M. Pathogenic mutations in retinitis pigmentosa 2 predominantly result in loss of RP2 protein stability in humans and zebrafish. J Biol Chem. 2017 Apr 14;292(15):6225-6239.
Liu F, Chen J, Yu S, Raghupathy RK, Liu X, Tang Z, Liu M. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Hum Mol Genet. 2015 Aug 15;24(16):4648-59.
