在Nature Biomedical Engineering, Chemical Society Reviews, Accounts of Chemical Research, Nature Communications, Nano Letters, ACS Nano,Advanced Functional Materials,Biomaterials,Small等杂志发表 SCI 论文 350 余篇,累计他引 9700 余次,H-index 53,连续七年入选2014-2020年Elsevier 发布的中国高被引学者榜单(药理学、毒理学和药剂学研究领域)。出版纳米药物相关专著 3 部。授权相关发明专利 50 余件;湖北省科技进步一等奖 1 项。获得中分子量羟乙基淀粉、酪蛋白铁、注射用间苯三酚等原料及制剂相关新药证书 3 项、药品注册批件 16 项。
代表专利: 1 一种雷公藤甲素固体脂质纳米颗粒及其制备方法和应用(CN201110139086.2)。杨祥良,林伟基,徐辉碧,易涛,刘卫,张聪,方伟,彭帆,邵莉。 2 一种抗癌药物羟乙基淀粉-多西紫杉醇偶联物制备方法(CN201310521645.5)。杨祥良,杨亚江,徐辉碧,柳轻瑶,万江陵。 3 一种两亲性羟乙基淀粉偶联聚乳酸共聚物及其制备方法和应用(CN201610875153.X)。杨祥良, 李子福, 万影, 徐辉碧, 余婵, 周庆。 4 一种RES巨噬细胞阻塞材料、肿瘤多步疗法系列药物及其应用(CN201610874998.7)。杨祥良, 李子福, 万影, 徐辉碧, 余婵, 周庆 5 一种水溶性稀土掺杂纳米晶体及其制备方法和应用(CN201610098222.0)。杨祥良,胡军,唐永安 6 聚N-异丙基丙烯酰胺温敏纳米凝胶中残留单体的纯化方法(CN201310108346.9)。赵彦兵,杨祥良,刘卫,孙海霞,李涵,张彦 7 瘤内注射用原位温敏聚合物凝胶纳米组合物及应用(CN201610105499.1)。赵彦兵,杨祥良,万江山,周小顺,耿石楠,赵浩,李涵。 8 肿瘤微环境智能响应的纳米凝胶及纳米凝胶载药系统(ZL201710006935.4)。甘璐,王芹,杨祥良,杨昊,李福英
9 一种从小肠浸出液中提取肝素和硫酸皮肤素的方法(CN201410047671.3)。朱俊铭、马继华、杨祥良
10 一种磁共振成像造影剂及其制备方法与应用(CN201510870335.3)。周琦冰,魏裕双,杨祥良
11 一种填充材料及其应用(CN201810028054.7)。 万江陵,岑培倩,杨祥良。
近五年主要项目: 1、“纳米研究”国家重大科学研究计划项目(973计划),肝癌治疗的新型纳米药物研究(2012CB932501),首席科学家,2723万元,2012.01.01-2016.08.31; 2、“重大新药创制”国家科技重大专项,武汉创新药物研究与开发技术体系建设—纳米载药系统与先进给药技术平台,主持,454.46万元,2011.01.01-2013.12.31; 3、国家自然科学基金面上项目,肿瘤干细胞来源的载药微颗粒抗肿瘤作用及机制研究(81773653),主持,60万元,2017.01-2020.12; 4、国家自然科学基金面上项目,基于温度/pH敏感纳米凝胶亲疏水性反转策略调控抗肿瘤药物体内过程(81473171),主持,60万元,2015.01-2018.12; 5、国家自然科学基金委员会重大科研仪器设备研制专项,多核素同步一体化肿瘤分子成像仪器研制(81627901),华科子课题负责人,249.68万元,2017.01.01-2021.12.31 6、华中科技大学“重大科技成果培育计划”(简称“登峰计划”)“纳米技术与肝癌诊断”研究团队,主要参与者,1000万元; |
[1] Zheng Li, Chen Xiao, Tuying Yong, Zifu Li*, Lu Gan*, Xiangliang Yang*. Influence of nanomedicine mechanical properties on tumor targeting delivery. Chemical Society Review, 2020, 49, 2273. [2] Qingle Liang, Nana Bie, Tuying Yong, Ke Tang, Xiaolong Shi, Zhaohan Wei, Haibo Jia, Xiaoqiong Zhang, Haiyan Zhao, Wei Huang, Lu Gan*, Bo Huang*, Xiangliang Yang*. The Softness of Tumour-Cell-Derived Microparticles Regulates Their Drug-Delivery Efficiency. Nature Biomedical Engineering, 2019, 3, 729-740. [3] Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu, Lu Gan*, Hélder A. Santos*, Xiangliang Yang*. Tumor Exosome-Based Nanoparticles are Efficient Drug Carriers for Chemotherapy. Nature Communications, 2019, 10(1), 3838. [4] Zifu Li, Chunzhi Di, Suping Li*, Xiangliang Yang*, Guangjun Nie*. Smart Nanotherapeutic Targeting of Tumor Vasculature. Accounts of Chemical Research, 2019, 52, 2703-2712. [5] Xiaoyan Zhong, Xianwen Wang, Liang Cheng,* Yong’an Tang, Guiting Zhan, Fei Gong, Rui Zhang, Jun Hu,* Zhuang Liu, and Xiangliang Yang*. GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy. Advanced Functional Materials, 2019, 1907954. [6] Hao Zhao, Jiabao Xu, Wenjing Huang, Guiting Zhan, Yanbing Zhao*, Huabing Chen*, Xiangliang Yang*. Spatiotemporally Light-Activatable Platinum Nanocomplexes for Selective and Cooperative Cancer Therapy. ACS Nano, 2019, 13(6), 6647-6661. [7] Yihui Li, Yuxin Wu, Jitang Chen, Jiangling Wan, Chen Xiao, Jiankun Guan, Xianlin Song, Shiyou Li, Mengmeng Zhang, Huangchen Cui, Tiantian Li, Xiaoquan Yang, Zifu Li*, Xiangliang Yang*. A Simple Glutathione-Responsive Turn-On Theranostic Nanoparticle for Dual-Modal Imaging and Chemo-Photothermal Combination Therapy. Nano Letters, 2019, 19(8), 5806-5817. [8] Xiaoyan Zhong, Xianwen Wang, Guiting Zhan, Yong’an Tang, Yuzhu Yao, Ziliang Dong, Linqian Hou, He Zhao, Songjun Zeng, Jun Hu,* Liang Cheng,* Xiangliang Yang*. NaCeF4:Gd,Tb Scintillator as an X-ray Responsive Photosensitizer for Multimodal Imaging-Guided Synchronous Radio/Radiodynamic Therapy. Nano Letters, 2019, 19, 8234-8244. [9] Hao Zhao, Jiabao Xu, Wenjing Huang, Yanbing Zhao*, Xiangliang Yang*. Thermosensitive Nanogels with Cross-Linked Pd(II) Ions for Improving Therapeutic Effects on Platinum-Resistant Cancers via Intratumoral Formation of Hydrogels. Chemistry of Materials, 2019, 31,5089-5103. [10] Xian Wu, Yanhong Zhu, Wei Huang, Jingqiu Li, Bixiang Zhang, Zifu Li*, Xiangliang Yang*. Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells. Advanced Science, 2018, 5(8), 1700859. [11] Hao Yang, Qin Wang, Zifu Li, Fuying Li, Di Wu, Man Fan, Anbi Zheng, Bo Huang, Lu Gan*, Yuliang Zhao*, Xiangliang Yang*. Hydrophobicity-Adaptive Nanogels for Programmed Anticancer Drug Delivery. Nano Letters, 2018, 18, 7909-7918. |