副教授

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孟凡玲

时间:2016-10-09     浏览次数:

 

孟凡玲
职称职务 副教授
学科专业 生物工程和生物化学
联系方式  027-65526252(电话)(传真)
电子邮箱 fanlingmeng@hust.edu.cn;团队介绍:http://liangluogroup.wqdian.cn/
 
教育经历 1997/9-2001/6 天津科技大学,化工系,学士
           2001/09-2004/06 南开大学,化学系,硕士
           2005/08-2010/08 美国纽约州立大学石溪分校,化学系,博士
工作经历 2013/01-2015/10 美国伦斯利尔理工学院,化学与生物工程系,博士后
学术兼职  
研究方向 (1)研究和二型糖尿病相关的淀粉样蛋白纤维的形成机理,并设计抑制剂抑制淀粉样蛋白的生成
(2)开发以淀粉样蛋白纤维为基础的新型材料

 

近年的科研项目、专著与论文、专利、获奖
近年来参与专著一部( Protein Misfolding Diseases: Current and Emerging Principles and Therapies)。在著名期刊如Journal of the American Chemical Society, Journal of Molecular Biology等发表SCI论文10余篇.
近五年代表性论文

1.Christine C. Lee, Mark Julian, Kathryn Tiller, Fanling Meng, Sarah DuConge, Rehana Akter, Daniel Raleigh, Peter M Tessier. “Design and optimization of anti-amyloid domain antibodies specific for beta-Amyloid and islet amyloid polypeptide” (2016) Journal of Biological Chemistry  291,2858-2873,
           2.Fanling Meng and Daniel P. Raleigh. “Sulfated Triphenyl Methane Derivatives are Potent Inhibitors of Amyloid Formation by pro-Islet Amyloid Polypeptide Processing Intermediates and also Inhibit Glycosaminoglycan Catalyzed Amyloid Formation” (2011) Journal of Molecular Biology, 406,491-502.
           3.Fanling Meng, Andisheh Abedini, and Daniel P. Raleigh “Combination of Kinetically Selected Inhibitors in Trans Leads to Highly Effective Inhibition of Amyloid Formation.”(2010) Journal of the American Chemical Society, 132, 14340-14342.
           4.Fanling Meng, Andisheh Abedini, Annette Plesner, Katherine J. Potter, C. Bruce Verchere and Daniel P. Raleigh. “The Flavanol (-)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity” (2010) Biochemisry, 49, 8127-8133.
           5.Fanling Meng, Andisheh Abedini, Annette Plesner, Katherine J. Potter, C. Bruce Verchere and Daniel P. Raleigh. “Sulfated Triphenyl Methane Derivatives are Potent Inhibitors of Amyloid Formation by Human Islet Amyloid Polypeptide and Protect against the Toxic Effect of Amyloid Formation” (2010) Journal of Molecular Biology, 400, 555-566

 



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