(Correspondent Xin Zhang) Recently, Bioactive Materials, the cutting-edge journal in the field of biomaterials, published the new work of Prof. Shengmin Zhang’s lab in the field of element-doped bioactive materials: Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis. Combining zinc and strontium ions with collagen molecular templates, a new type of bone-like apatite material (ZnSr-Col-HA) was developed through a biomimetic co-assembly strategy. ZnSr-Col-HA could promote osteogenic differentiation of mesenchymal stem cells by modulating the osteo-immune microenvironment and procedural releases of zinc and strontium ions, providing new inspiration and significant prospects for bone regeneration (Figure 1). This is another new progress made by Prof. Zhang’s team following the invention of selenium-doped bioactive material applied for bone regeneration after the malignant bone tumor resection (Biomaterials,2020; ACS Nano,2016; Adv Healthc Mater,2015; Interface Focus,2012).
Figure 1: ZnSr-Col-HA promotes bone repair through osteogenic immunomodulation and osteogenesis
PhD candidates Zhenyu Zhong and Xiaodan Wu from Huazhong University of Science and Technology are the co-first authors of the paper. Dr. Yingying Du and Prof. Shengmin Zhang are the co-corresponding authors.
Previously, Prof. Shengmin Zhang's team has developed a series of functional elements-doped CaP bioactive bone substitute materials, including magnesium doped bone-like apatite materials (Bioactive Materials,2020; JBMR-A,2019; etc.), silicon doped bone-like apatite materials (J Control Release,2017; Biomed Mater,2015; Biomed Mater,2008), zinc doped bone-like apatite materials (Mater Sci Eng C,2012; Cryst Growth Des,2015), strontium doped bone-like apatite materials (Biomed Mater,2018), etc. Meanwhile, Prof. Shengmin Zhang's team has developed a series of bioactive inorganic calcium phosphate/organic hybrid biomaterials through dual-template biomimetic mineralization strategy originally proposed by the team(Nanoscale,2017; Biomacromolecule,2015; Biotechnology Advances,2014; JBMR-A, 2012; JBMR-A,2011; etc.). The above mentioned highly bioactive materials provide an enormous personalized library of key "core materials" to construct next-generation of high-performance biomaterial devices with a wide range of application prospects.
Before the publication of relevant papers, the above-core achievements have applied for domestic and overseas patents or obtained patent authorization, and realized industrial production with the establishment of the world's largest CaP bioactive material manufacturing base.