题目：1. Oncogenesis of Lymphoid Malignancy
2. Chronic Toxicity of TiO2 Nanoparticles
主讲人：张渊（Yung Chang) 副教授
美国亚立桑那州立大学，生命科学院及生物设计研究所
时间：2009年12月9日（星期三）上午9：00
地点：生命科学与技术学院（东十一楼）二楼会议室
报告人简介：
1. 医学学士（1978 --1983， 北京医学院，基础医学系）
2. 免疫博士（1983--1988， University of Iowa, 病理系）
3. 分子生物学博士后 （1988－1990： Boston University, 生化系)
研究领域： c-myc 肿瘤基因的转录调控
4. 免疫博士后 （1991－1996： Fox Chase Cancer Center, 免疫组）
研究领域：免疫缺陷的分子机制
实验室主要从事于：1）淋巴细胞发育发生及淋巴癌的癌变机制；2）构造抗瘤多原适体；3）纳米材料的潜在隐患。
报告摘要：
1.Oncogenesis of Lymphoid Malignancy
Genome instability is a hallmark of a cancer cell, responsible for its initial oncogenic transformation and further disease progression. The lymphoid specific recombination system has been implicated in initiating illegitimate recombination at pro- or anti- oncogenes, leading to lymphomagenesis. To elucidate molecular processes and causal connection between illegitimate recombination and oncogenesis, we created an inducible model, i.e., inducible for recombination, inducible for genome instability and inducible for tumor formation. This model allows us to delineate the molecular processes of illegitimate recombination in a step-wise fashion, proceeding from an initial illegitimate recombination cleavage to its resolution, and to assess the effect of illegitimately recombined products on cell survival and growth, ultimately on tumor formation.
2.Chronic Toxicity of TiO2 Nanoparticles
As common nanomaterials, TiO2 nanoparticles (nTiO2) that are perceived as safe materials, have already been widely used in a variety of consumer products, such as sunscreens, cosmetics, paints, surface coatings, and food additives as well as in the environmental decontamination of air, soil, and water. Such perception might have resulted from some short-term studies that reveal no or low toxicity of nTiO2 to cells or eco-relevant organisms. However, the long-term impact of nTiO2 to both human health and environment may still be a concern. Here, for the first time, we demonstrated that chronic exposure of zebrafish to a dose as low as 0.1 mg/L of nTiO2 could perturb zebrafish reproduction. This finding implies that the organisms in the nTiO2-contaminated aquatic environment may face potential risk of losing their reproduction activity, ultimately changing the population dynamic of aquatic organisms, as well as ecosystem balance. Our data also highlights the importance of long-term studies in assessing nanoparticle implication in human heath and environmental safety. These studies will provide critical information to formulate possible new standards, regulation and guideline in dealing with NP nanoparticle contamination in the aquatic environment.
