题目：The Mammalian Golgi Regulates Self-renewal and Differentiation of Neural Stem Cells
主讲人：周严 博士
耶鲁大学分子细胞和发育生物学系
时间：4月22日（星期四）上午10:00
地点：生命科学与技术学院八楼会议室
报告人简历：
教育经历
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中国协和医科大学,中国医学科学院
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获医学博士
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2000年9月 – 2002年7月
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中国协和医科大学,中国医学科学院
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获理学博士
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导师: 强伯勤院士, 袁建刚教授
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1997年9月 – 2000年7月
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同济医科大学临床医学7年制
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获医学学士
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1991年9月 – 1997年7月
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工作经历
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耶鲁大学分子细胞和发育生物学系
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Associate Research Scientist
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2007年4月至今
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耶鲁大学分子细胞和发育生物学系
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博士后
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2002年8月 – 2007年3月
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研究经历
2002年8月至今耶鲁大学分子细胞和发育生物学系Weimin Zhong（钟伟民）教授实验室
研究神经干(前体)细胞通过非对称细胞分裂调控细胞决定的机制，特别是Numb及相关蛋白如何调控非对称细胞分裂，从而影响神经干细胞维持和分化的机制。
1997年9月 – 2002年7月医学分子生物学国家重点实验室，中国协和医科大学基础医学研究院，中国医学科学院基础医学研究所强伯勤院士, 袁建刚教授实验室
神经系统表达新基因的克隆表达和功能研究
获奖情况
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Judges Travel Subsidy Award, ABRCMS
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2007
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医学博士/理学博士奖学金，美国中华医学基金会（纽约）
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1997-2002
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三好学生, 中国协和医科大学
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1998-1999
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三好学生，优秀学生干部，同济医科大学
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1991- 1997
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教学经历
Participation and successful completion in the Fundamentals of Teaching Labs workshop, Yale College and Yale Graduate School 2007
Mentoring undergraduate researchers, Yale University 2005-2007
Participation and successful completion in the seminar series, Mentoring Undergraduate Researchers, Yale College and Yale Graduate School 2005
Mentoring graduate and undergraduate researchers, Peking Union Medical College 1998-2002
发表文章
1. Zhou, Y. et al. ACBD3 and MRGI play redundant roles in Numb-mediated asymmetric cell fate specification during neural development. In preparation (intended for Nature Neuroscience or Genes & Development)
2. Zhou, Y. et al. Arf1 regulates cell-cycle dependent ACBD3 Golgi association. In preparation (intended for Journal of Cell Biology)
3. Zhou, Y., Atkins, J., Rompani, S., Bancescu, D., Tang, H., Petersen, P., Zou, K., Stewart, S., Zhong, W. (2007) The mammalian Golgi regulates Numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell 129 (1): 163-78 (IF=31.3)
4. Zhou, Y., Du, G., Hu, X., Yu, S., Liu, Y., Xu, Y., Huang, X., Liu, J., Yin, B., Fan, M., Peng, X., Qiang, B., Yuan, J. (2005) Nectin-like molecule 1 is a protein 4.1 N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochimica et Biophysica Acta-Biomembranes, 1669(2): 142-54 (IF=4.2)
5. Tang, H., Rompani, S. B., Atkins, J. B., Zhou, Y., Osterwalder, T., and Zhong, W. (2005). Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway. Molecular and Cellular Biology 25: 2899-2909 (IF=6.4)
6. Yang, H., Zhou, Y., Hu, X., Xu, Y., Yin, B., Zhu, S., Fan, W., Fan, M., Qiang, B., Yuan, J., and Peng, X. (2005) Human nectin-like 1, a novel membrane protein interacting with protein 4.1 R. Progress in Natural Science, 15 (2) : 189-192. (IF=0.5)
7. He, HL., Wu, ZH., Zhang, JG., Wang, YP., Zhou, Y., Xu, YQ., Yuan, J., Qiu, GX. (2005) The expression of collagen IX in the apical disc of idiopathic scoliosis. Chinese Journal of Surgery, 43 (8): 513-6
8. Huang, X., Yang, H., Zhou, Y., Liu, J., Yin, B., Peng, X., Qiang, B., and Yuan, J. (2004). Overexpression of human reticulon 3 (hRTN3) in astrocytoma. Clinical Neuropathology, 23: 1-7. (IF=0.8)
9. He, HL., Wu, ZH., Zhang, JG., Wang, YP., Zhou, Y., Xu, YQ., Yuan, J., Qiu, GX. (2004) Primary study on collagen X gene expression in the apical disc of idiopathic scoliosis. Chinese Medical Journal, 84 (20): 1681-1685
10. Zhou, Y., Hu, S., Huang, X., Zhou, H., Tan, X., Peng, X., Qiang, B., Yuan, J. (2002) Construction of human and mouse brain cDNA libraries and isolation of full-length cDNAs. Progress in Natural Science, 12(6): 477-480 (IF=0.5)
11. Liu, Y., Fan, M., Yu, S., Zhou, Y., Wang, J., Yuan, J., and Qiang, B. (2002). cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Brain Research 928:147-155.
12. Li, G., Lu, H., Zhou, Y., Jin, J., Jiang, K., Peng, X., Yuan, J., and Qiang, B. (2002). Cloning and characterization of human ubiquitin binding enzyme 2 cDNA. Chinese Medical Sciences Journal 17, 7-12.
13. Hu, X. Y., Zhou, Y., Dai, Y., Chen, J. M., Zhang, B., Peng, X. Z., Yuan, J. G., and Qiang, B. Q. (2002). [The cloning and prokaryotic expression of human tumor necrosis factor like protein]. Acta Academiae Medicinae Sinicae, 24 (3), 246-249.
14. Zhou, Y., Hu, X., Wang, H., Peng, X., Yuan, J. (2002) Interaction between membrane proteins and cytoskeleton proteins. Journal of Chinese Biotechnology, 22 (1) 33-38
15. Chen, JH., Liu, XQ., Guo, YP., Zhou, Y., Yuan, JG. (2002) Clinical characteristics of patients with paraneoplastic neurological syndrome in PUMC hospital from 1990 to 2000. Journal of Apoplexy and Nervous Disease, 19 (2) 96-97
16. Chen, JH., Liu, XQ., Guo, YP., Zhang, B., Zhou, Y., Hu, XY., Yuan, JG., Qiang, BQ., Peng, XZ. (2002) Cloning, expression and purification of neural specific HuD cDNA. Acta Academiae Medicinae Sinicae, 24 (3): 250-253
17. Wang, J., Zhou, Y., Yin, B., Du, G., Huang, X., Li, G., Shen, Y., Yuan, J., and Qiang, B. (2001). ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of Molecular Medicine, 79, 399-405. (IF=4.4)
18. Hu, X., Zhou, Y., Yuan, J., Qiang, B. (2001) Research progress in protein 4.1 gene family. Progress in Biochemistry and Biophysics, 28 (3): 290-294
19. Liu, Y., Yu, S., Zhou, Y., Wang, J., Liu, S., Yuan, J., Qiang, B, Fan, M. (2001). cDNA isolation, chromosomal mapping and genomic analysis of human homeobox gene LHX4. Chinese Journal of Biochemistry and Molecular Biology, 17 (5): 552-556
20. Hu, X., Zhou, Y., Yuan, J., Qiang, B. (2001) Progress in neural system cell adhesion molecules. Chinese Bulletin of Life Sciences, 13 (5): 200-205
21. Zhou, H., Huang, X., Zhou, Y., Li, G., Yin, B., Ma, Y., Peng, X., Yuan, J., Qiang, B. Cloning and prokaryotic expression of HGLP cDNA. (2001) Chinese Science Bulletin, 46 (13), 1089-1092 (IF=0.77)
22. Du, G., Pan, M., Zhou, Y., Chen, J., Yao, H., Yuan, J., Qiang, B. (2000) Cloning of human and mouse GRY-RBP cDNA. Chinese Science Bulletin, 45 (4), 343-350 (IF=0.77)
23. Luo, W., Chen, J., Zhou, H., Huang, X., Zhou, Y., Yuan, J., Qiang, B. (2000) Cloning and expression of a novel human HCUTA cDNA. Chinese Science Bulletin, 45 (14), 1301-1304
24. Lu, H., Li, G., Zhou, Y., Jin, J., Jiang, K., Peng, X., Yuan, J., and Qiang, B. (2000). [The identification and cloning of human ubiquitin binding enzyme cDNA]. Acta Academiae Medicinae Sinicae, 22(4), 306-311.
25. Chen, J., Luo, W., Zhou, Y., Tan, X., Li, G., Huang, X., Zhou, H., Li, W., Yuan, J., Qiang, B. (2000) Cloning and eukaryotic expression of Human HCL cDNA. Progress in Natural Science, 10 (11): 1001-1005
26. Du, G., Zhou, Y., Chen, J., Wang, J., Yin, B., Yuan, J., Qiang, B. (2000). Clonng and expression analysis of MBLL cDNA. Chinese Science Bulletin, 45(7): 620-625. (IF=0.77)
27. Du, G., Zhou, Y., Chen, J., Wang, J., Huang, X., Yuan, J., Qiang, B. (1999) Expression of human GRY-RBP and analysis of its RNA binding activities. Chinese Journal of Biochemistry and Molecular Biology, 15 (6): 866-870
28. Zhou, Y., Du, G., Wang, J., Chen, J., Yuan, J., Qiang, B. (1999) Isolation and cloning of a novel cDNA LDB1 encoding human LIM domain binding protein. Chinese Science Bulletin, 44(12): 1114-1119. (IF=0.77)
29. Wang, J., Du, G., Zhou, Y., Yin, B., Yuan, J., Qiang, B. (1999) Cloning and identification of PHF2 cDNA and its alternatively spliced transcripts. Chinese Science Bulletin, 44(15), 1382-1387 (IF=0.77)
30. Du, G., Zhou, Y., Yuan, J., Qiang, B. (1999) RRM RNA binding protein: Structure and function. Progress in Biochemistry and Biophysics, 26 (4): 305-307.
31-38. 略：1999-2001期间在中文期刊所发表文章
口头报告
1. The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis. (2007). Gordon Research Conferences – Developmental Biology, June 24th.
2. A Novel Cell-Cycle Dependent Mechanism for Specifying Asymmetric Cell Fates During Mouse Neurogenesis. (2005) Research in Progress seminar - Department of Molecular, Cellular and Developmental Biology, Yale University
张贴报告
1. Zhou, Y., Zou,K., Zhong, W. (2008) The Golgi membrane regulates asymmetric cell division of neural progenitor cells by releasing ACBD3 during mitosis. 73rd Cold Spring Harbor Symposium - Control & Regulation of Stem Cells
1. Petersen, P.H., Zou, K., Zhou, Y., Krauss, S., Zhong, W. (2003) Mouse Numb and Numblike are required for progenitor cell maintenance throughout neurogenesis. Program No.136.7.2003 Washington, DC: Society for Neuroscience, 2003.
2. Hu, X., Zhou, Y., Xu, Y., Zhu, S., Peng, X., Yuan, J., Qiang, B. (2002) A novel member of the immunoglobulin superfamily with homology to the poliovirus receptor and nection family, nectin like protein 2. HGM2002 Poster No. 193.
3. Huang, X., Liu, J., Zhou, Y., Yang, H., Qiang, B., Yuan, J. (2002) NSPL1, a member belonging to RTN family associated with the differentiation of brain tumor. HGM 2002 Poster No. 194.
4. Zhou, Y., Han, C., Wang, H., Hu, X., Li, G., Huang, X., Yuan, J., Qiang, B. (2001) Characterization of a neuronal protein 4.1 associated protein – NFA1. HGM2001 Poster No. 35.
5. Huang, X., Zhou, Y., Li, G., Liu, J., Yuan, J., Qiang, B. (2001) Cloing and characterization of two cDNA clones highly expressing in brain. HGM2001 Poster No. 13.
译著
《基因组学》主译：袁建刚周严强伯勤 (原著：Genomes by Brown, T.A., 2000) ISBN 7-03-010114-6/Q.1136, 507页
