[报告题目] Development Path and Current Status of the NANIVID: A New Device for Cancer Cell Studies
报告人：Professor James Castracane, College of Nanoscale Science and Engineering, University at Albany, State University of New York
时间：2011年4月18日（周一）14:30-16:00
地点：光电国家实验室A202
报告摘要：
In-vivo cancer cells create a unique microenvironment which helps them to spread to other organs. To understand the tumor microenvironment, special tools and devices are required to monitor the interaction among different cell types as well as the effects of particular chemical gradients. This study presents the design and optimization of a new, versatile chemotaxis device called the NANIVID (NANo IntraVital Imaging Device). The device is fabricated using MEMS techniques and consists of etched Pyrex substrates, a chemoattractant reservoir, fluorescent beads and a microelectrode array for cell quantification. This reservoir contains a customized hydrogel blend loaded with EGF which diffuses out to create a chemotactic gradient. This reservoir sustains a steady release of growth factor into the surrounding environment for many hours establishing a consistent concentration gradient from the device to attract specific cells. The focus of this study is to design and optimize the new device for chemotaxis studies in breast cancer cells in vitro and ultimately, implantable for in vivo work. The current development and testing status of the device will be presented against a backdrop of the College of Nanoscale Science and Engineering (CNSE) of the University at Albany which will include an overview of the infrastructure, personnel and operational model used by CNSE to integrate basic research with eventual technology deployment.
报告人简介：Professor James Castracane
l Head of Nanobioscience Constellation, Director of Technology, and Founding Faculty of the College of Nanoscale Science and Engineering
l Expert in Micro/Nano-Electro-Mechanical Systems (M/NEMS), Electro-optics, Nanobioscience and Biomedical instrumentation
l Member of American Physical Society, SPIE, Optical Society of America, and American Society for Nanomedicine
l Member of NIH Review panels and the Review Committee-Defense Sciences Research Council (DARPA)
l Reviewer for Nanomedicine: Nanotechnology, Biology and Medicine, Micro and NanoSystems, Review of Scientific Instruments, Journal of Microlithography, Microfabrication, and Microsystems, Optical Engineering, Journal of Quantum Electronics, Optical Society of America
l More than 150 Publications of Journal articles, including Biomaterials, Analytical Chemistry, Biosensors & Bioelectronics, Applied Physics Letters, Review of Scientific Instruments, Journal of Microelectromechanical Systems, Journal of Microlithography, Microfabrication, and Microsystems
