学术报告—The many faces of a nuclear protein, HMGB1
报告人： Huan Yang, MD, PhD. Associate Investigator，Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY
报告内容简介： Dr. Huan Yang received an MD degree in China and a PhD from the University of Wisconsin-Madison. After having two post-doctoral training at University of Texas, Health Science Center at San Antonia and at National Institute of Health, Baltimore of Maryland, she joined the Feinstein Institute in 2000. Dr. Yang studies the immune system and diseases caused by inflammation, and her research focus is sepsis. Investigators at the Feinstein Institute discovered a ubiquitous nuclear protein, HMGB1, as a critical late-acting pro-inflammatory mediator for lethal systemic infection including sepsis. Dr. Yang and her team has been studying the molecular basis of inflammation mediated by this newly identified cytokine HMGB1, as well as searching for experimental therapies to block HMGB1, in order to develop improved treatment for severe sepsis. Specifically, Dr. Yang and her team are using DNA-conjugated beads to sequester HMGB1 in murine colitis in mice. HMGB1 acts as a cytokine mediator of inflammation in the pathogenesis of inflammatory bowel disease (IBD). Since HMGB1 binds to DNA with high affinity, Dr. Yang has developed oligonucleotides immobilized onto sepharose beads and used them as a novel agent to sequester HMGB1 in treatment of IBDs. In addition, Dr. Yang, along with Drs. Tracey and Al-Abed, have identified a tetra-peptide (5779) as a specific MD-2-targeting antagonist, which prevents MD-2/HMGB1 interaction, reduces HMGB1 -mediated cytokine production and confers protection in animal models of severe sepsis.
时间：2014年4月22日（星期二）上午 10:00-11:00
地点：生命科学与技术学院二楼会议室
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